Abstract: Qinling-Daba Mountains have been the main body of the north-south transition zone in China, and their geographical location and natural conditions make them unique in terms of biogeographic distribution and significance. As the key ecological barrier in Central China, Qinling-Daba Mountains are also key areas for biodiversity. Based on the analysis of the current situation of the natural protected areas, it can be seen that the spatial distribution in this region was a cluster-type distribution as a whole. In terms of composition, the nature reserves and forest parks were the main ones, supplemented by geoparks and wetland parks. In the spatial relationship, there were 34 spatial overlaps involving 60 protected areas, mainly in the Micang Mountains, the Taizi Mountains in the Western Qinling Mountains, the Shennongjia and the Funiu Mountains. These overlaps belonged to 6 types, mainly the nature reserve-forest park overlap, reflecting the historical legacy of their early establishment. Therefore, it is necessary to focus on and improve those nature reserves that were not planned properly, have spatial overlaps, and were fragmented, to promote the integration and optimization of protected areas and the formation of a scientific and rational layout in the Qinling-Daba Mountains.