Abstract: The Qinling Mountains is one of the regions with the most intensive nature reserves in China, and it is also an important ecological protection barrier in China. There are many national nature reserves in the middle of the Qinling Mountains, however, there has been few study on the vegetation growth status, and the protection effectiveness of the nature reserves is still unclear. Therefore, exploring the long-term vegetation growth status in this area can be helpful to understand the protection effectiveness and vegetation growth of nature reserves in the middle of the Qinling Mountains. This paper used Landsat, MODIS, GLASS, and other remote sensing data and related products to analyze the spatial distribution characteristics and trend of normalized vegetation index (NDVI), leaf area index (LAI), net primary productivity (NPP), and vegetation coverage (FVC). The comprehensive four indicators were used to explore the vegetation growth status and protection effects of nature reserves in the middle of the Qinling Mountains. The conclusions were as below: 1) In terms of space characteristic, the vegetation types in the south-central Taibai Mountain Nature Reserve and the southern part of the Hanzhong Crested Ibis Nature Reserve was different from others; 2) In terms of trends, the vegetation growth status of nature reserves were in a significant increase trend or maintained stable; 3) Comprehensive the indicators found that the overall protective effect of nature reserves in the middle of Qinling Mountains were good, but very few areas still needed to be focused on.